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Infectious Disease: Hepatitis C

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Total 11845 results found since Jan 2013.

Approved and experimental countermeasures against pestiviral diseases: Bovine viral diarrhea, classical swine fever and border disease.
Abstract The pestiviruses, bovine viral diarrhea virus (BVDV), classical swine fever (CSFV) and border disease virus, are important livestock pathogens in many countries, but current vaccines do not completely prevent the spread of infection. Control of pestiviral diseases is especially difficult due to the constant viremia and viral shedding of persistently infected (PI) animals, which must be identified and eliminated to prevent disease transmission. Existing vaccines are limited by the delay between vaccination and the onset of protection, the difficulty of differentiating serologically between vaccinated and n...
Source: Antiviral Research - August 5, 2013 Category: Virology Authors: Newcomer BW, Daniel M Tags: Antiviral Res Source Type: research

Novel thioglycosyl analogs of glycosyltransferase substrates as antiviral compounds against classical swine fever virus and hepatitis C virus.
Abstract Hepatitis C virus (HCV) and classical swine fever virus (CSFV) are important pathogens for which new therapeutic approaches are in high demand. Herein, we report the synthesis of newly designed thioglycosyl analogs of glycosyltransferase substrates which were evaluated using cell-based assays for cytotoxicity and antiviral activity against both viruses. The antiviral activity of synthesized compounds against CSFV and HCV was confirmed using pseudo-plaque reduction assays where a significant arrest of viral growth was observed in the presence of selected compounds. We showed that compounds 13 and 14 exerte...
Source: European Journal of Medicinal Chemistry - May 31, 2017 Category: Chemistry Authors: Pastuch-Gawolek G, Chaubey B, Szewczyk B, Krol E Tags: Eur J Med Chem Source Type: research

Gold nanoparticles enhance immune responses in mice against recombinant classical swine fever virus E2 protein.
CONCLUSIONS: This finding demonstrated the potential of using AuNPs as a carrier to enhance the body's immune response for developing CSFV subunit vaccines. This model also contributes to the development of other flavivirus subunit vaccines, such as hepatitis C virus (HCV) and bovine viral diarrhea virus (BVDV). PMID: 32140883 [PubMed - as supplied by publisher]
Source: Biotechnology Letters - March 4, 2020 Category: Biotechnology Authors: Li Y, Jin Q, Ding P, Zhou W, Chai Y, Li X, Wang Y, Zhang G Tags: Biotechnol Lett Source Type: research

Swine Flu's Death Toll May Be Much Higher Than Thought
Title: Swine Flu's Death Toll May Be Much Higher Than ThoughtCategory: Health NewsCreated: 11/26/2013 5:36:00 PMLast Editorial Review: 11/27/2013 12:00:00 AM
Source: MedicineNet Hepatitis C General - November 27, 2013 Category: Infectious Diseases Source Type: news

SemEHR: A general-purpose semantic search system to surface semantic data from clinical notes for tailored care, trial recruitment, and clinical research*
ConclusionResults from the multiple case studies demonstrate SemEHR ’s efficiency: weeks or months of work can be done within hours or minutes in some cases. SemEHR provides a more comprehensive view of patients, bringing in more and unexpected insight compared to study-oriented bespoke IE systems. SemEHR is open source, available athttps://github.com/CogStack/SemEHR.
Source: Journal of the American Medical Informatics Association - January 19, 2018 Category: Information Technology Source Type: research

Active search for hepatitis C patients in Primary Care
CONCLUSIONS: Active search for patients with hepatitis C in PC together with the OSD are effective measures to detect hidden infections and to increase the number of treatments, contributing to the elimination of hepatitis C.PMID:34284593 | DOI:10.17235/reed.2021.8067/2021
Source: Revista Espanola de Enfermedades Digestivas - July 21, 2021 Category: Gastroenterology Authors: Luc ía Seoane Blanco Javier Soto S ánchez Gema Sierra Dorado Leire Parapar Álvarez Manuel Crespo S ánchez Luis S ánchez Domínguez Juan de la Vega Fern ández Source Type: research

The search for nucleoside/nucleotide analog inhibitors of dengue virus.
This article forms part of a symposium in Antiviral Research on flavivirus drug discovery. PMID: 26241002 [PubMed - as supplied by publisher]
Source: Antiviral Research - August 1, 2015 Category: Virology Authors: Chen YL, Yokokawa F, Shi PY Tags: Antiviral Res Source Type: research

Next-Generation Sequencing of 5' Untranslated Region of Hepatitis C Virus in Search of Minor Viral Variant in a Patient Who Revealed New Genotype While on Antiviral Treatment.
In conclusion, longitudinal analysis of HCV variants, employing two independent deep sequencing methods, suggests that the transient presence of a different genotype strain in PBMC was a result of superinfection and not a selection of pre-existing minor variant. PMID: 26747069 [PubMed - as supplied by publisher]
Source: Advances in Experimental Medicine and Biology - January 16, 2016 Category: Research Tags: Adv Exp Med Biol Source Type: research

Hepatitis C point-of-care diagnostics: in search of a single visit diagnosis.
Authors: Grebely J, Applegate TL, Cunningham P, Feld JJ Abstract INTRODUCTION: The availability of simple, tolerable, therapies for hepatitis C virus (HCV) infection with responses >95% is one of the greatest medical advances in decades, offering an opportunity to reverse the rising burden due to HCV and strive towards HCV elimination. A key challenge moving forward will be to ensure that those who are undiagnosed are made aware of their infection, receive HCV therapy and achieve viral cure. The availability of point-of-care tests for HCV infection has the potential to simplify testing algorithms, increase diagn...
Source: Expert Review of Molecular Diagnostics - November 2, 2017 Category: Laboratory Medicine Tags: Expert Rev Mol Diagn Source Type: research

An update on recent developments in the search for hepatitis C virus therapies with pan-genotypic efficacy.
Authors: Borgia G, Scotto R, Buonomo AR Abstract INTRODUCTION: Pangenotypic drugs against HCV infections led to high rates of virologic response with very limited adverse events. Moreover, they are easy to administer among all HCV genotypes with minimal changes in treatment schedule. For this reason, the demand for new antivirals is greatly lowered. Areas covered. We discuss results from trials assessing safety and efficacy of Ravidasvir, which is the only direct-acting antiviral currently in clinical development. Expert opinion. The currently available pangenotypic drug combinations are very effective in HCV eradi...
Source: Expert Opinion on Investigational Drugs - April 6, 2019 Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research

Patients with hepatitis C lost to follow-up: ethical-legal aspects and search results.
CONCLUSION: a large number of patients with hepatitis C are lost to follow-up. Searching for and contacting these patients is legally and ethically viable. PMID: 32579001 [PubMed - as supplied by publisher]
Source: Revista Espanola de Enfermedades Digestivas - June 25, 2020 Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research

Egypt’s Poor Easy Victims of Quack Medicine
Many pharmacies and herbalists in Egypt prescribe their own 'wasfa' (secret drug or herbal elixir). Credit: Cam McGrath/IPSBy Cam McGrathCAIRO, Aug 10 2014 (IPS) Magda Ibrahim first learnt that she had endometrial cancer when she went to a clinic to diagnose recurring bladder pain and an abnormal menstrual discharge. Unable to afford the recommended hospital treatment, the uninsured 53-year-old widow turned to what she hoped would be a quicker and cheaper therapy. A local Muslim sheikh claimed religious incantations, and a suitable donation to his pocket, could cure the cancer. But when her symptoms persisted, Ibrahim cons...
Source: IPS Inter Press Service - Health - August 10, 2014 Category: Global & Universal Authors: Cam McGrath Tags: Civil Society Education Featured Headlines Health Human Rights Middle East & North Africa Poverty & MDGs Projects Women's Health AIDS avian flu blood dialysis clinics Corruption Doctors Egypt Health care Hepatitis C h Source Type: news

Aethlon ’ s blood filtration device as broad countermeasure for infectious diseases
In the midst of a devastating global crisis 2 years ago, a Ugandan physician was infected with Ebola in Sierra Leone as he was treating patients. He was hospitalized at the Frankfurt University Hospital and 12 days later he was unconscious, suffering from multiple organ failure. By the time Aethlon Medical (NSDQ:AEMD) got permission to use its Hemopurifier device, the doctor required mechanical ventilation, continuous dialysis and vasopressor medications. After almost 7 hours of treatment with the single cartridge blood filtration device, the patient’s viral load dropped from 400,000 virus copies per milliliter of b...
Source: Mass Device - November 18, 2016 Category: Medical Equipment Authors: Sarah Faulkner Tags: Blood Management Food & Drug Administration (FDA) Research & Development Aethlon Medical Inc. MassDevice Q&A Source Type: news